GWAS Annotated: PCSK6

Gene: proprotein convertase subtilisin/kexin type 6

GeneGHIDGWAS HitLead SNP-log10PTypeScoreEliteAssociation EvidenceLocationExternal LinksTFBSs
PCSK6GH15J101022-None0.0000Enhancer226EliteeRNA_co-expressionchr15:101022978-101025286ENSR15_BQ3BQ
NR2F2CEBPBEP300NFE2L2FOSCEBPBMAFKPOLR2A
PCSK6GH15J101293-15:101297404:G:A0.4659Promoter/Enhancer661EliteDistancechr15:101293014-101297693ENSR15_93H7JG, ENSR15_CD3DF, ENSR15_84ZF4Z, ENSR15_CD3DJ, ENSR15_93H7KJ, SNRPA1_1
TBX21ELF1PAX8BHLHE40ZBED1PAX5BACH1RBFOX2MTA2RAD51NRF1CBFBZEB2ZNF24POLR2AL3MBTL2BCORCTCFSREBF1IKZF1HDAC1RBFOX2BHLHE40SP1CHD1WRNIP1RFX1EBF1CTCFSMARCE1IKZF2ZFXSIN3AELF1TBPSAP30TAF1YY1ELF4MAXATF7ETV4RBFOX2MYCPHF8POLR2AMNTMXI1ZNF687EP400HDAC1ZZZ3EP300SRFPKNOX1BHLHE40UBTFPOLR2GASH2LMEF2BZNF24HNRNPLLNFYBRNF2MGAZNF592L3MBTL2KDM5AHDAC2NRF1RBBP5ZNF639MLLT1RBM22PCBP1ZNF316SREBF2POU2F2IKZF1CLOCKGATAD2BSAFBE2F4STAT1RBM39RCOR1PRPF4RESTNFIBNFICGATA1DPF2ZNF143SP1RELBHNRNPUL1NR2F2ARID3ATAF15BACH1SMAD5TCF7L2CREB3L1SKILFUSZNF263TBL1XR1ZNF217CTBP1EGR1SMAD1FOSL2HNRNPKGABPB1ATF3ZBTB33XRCC5NCOR1ZBED1ELF4GMEB1U2AF1CBX3FIP1L1C11orf30ZNF444SUZ12AGO2ZNF207MEIS2JUNTAF7SMARCA5CUX1TBPE2F7RBM25ARNTE2F8TFAP4GATA2HCFC1CREB1ESRRASTAT5AMTA3SOX6NEUROD1E2F1ELF1FOXM1ZHX2ZBTB7BCREMGATAD2AE2F6MBD2ETS1HNF4ANCOA4KDM4BAGO1TRIM22NR2C2RB1JUNDELK1TCF12RAD51TAF9BSKINR3C1ZBTB40ZNF639KLF5MAFKZBTB7AGABPAFOXK2SMARCA4USF1IRF1SIX5CBFBNBNFOSL1ZMIZ1KDM5ANFE2L2KDM4AGATA3MEF2CTHAP1RUNX3SIN3BSRFE4F1GATA4TRIM24STAT3FOXA1PAX5BCL3ZBTB11ATF7SAP30NCOA1NCOA6HES1PHF20RFX5AFF1ETV4NR2C1ZSCAN29ARID1BPMLZNF830KDM5BRFX1MTA2PTBP1RBM22UBTFMITFNR2F6NR2F1HNF4AHNF4GCBFA2T3PKNOX1MEIS2JUNDGATA3GATAD2BZFXTBPMYCFOSNR3C1CEBPB
PCSK6GH15J101300-15:101300449:C:T1.1472Enhancer121-Distancechr15:101300415-101300565ENSR15_93H7LH, ENSR15_5TSBQM
CTCFZNF444TRIM22SMC3RAD21ZNF143ZNF384SIN3AREST
PCSK6GH15J101320-15:101321178:G:A1.0257Enhancer258EliteDistancechr15:101320221-101321444ENSR15_BQ4WN, ENSR15_5TSG9C
POLR2AGABPACTCFMAXCEBPBZNF143RAD21
PCSK6GH15J101324-15:101324170:C:T0.7812Enhancer176-Distancechr15:101324103-101325476-
KDM1ASP1MAXATF7RXRAATF3EP300EGR1SPI1HNF4GFOXA1HNF4ACEBPBSMC3FOSL2ELF1MAFFYY1HNF4AHNRNPLJUNDNR2F2HNF4GSP1MAXRXRAATF3AGO2POLR2G
PCSK6GH15J101325-15:101325839:G:A0.8033Enhancer1-Distancechr15:101325753-101326109-
HNRNPLAGO2
PCSK6GH15J101333-15:101333787:T:C1.1634Enhancer219-Distancechr15:101333206-101335123ENSR15_93H7Z7, ENSR15_93H7Z9, ENSR15_84ZFXP
CTCFGABPB1NCOA1EP400BRD4NR2C1PHF20IKZF2POLR2AGABPAPHF8ZBTB40KDM5BMTA3TRIM28TRIP13MTA2CREB3L1PKNOX1SMAD5ZNF263EHMT2ATF7SP1E2F1CBX1E2F8RBFOX2ZNF184CREMCBX3BCL3MAXSETDB1ZBTB11TCF12FOXK2JUNPMLELF1SIX5ETS1HCFC1TBL1XR1NR2C2EGR1MYCJUNDATF2TAF1NFE2E4F1CTBP1C11orf30CBX5KDM4BZNF830HDAC1NFRKBATF7ZNF184ZNF316L3MBTL2PKNOX1KLF5RESTPHF20DNMT1MTA2RB1TRIP13PHF8CBX1SIN3BNFATC3
PCSK6GH15J101348-15:101348870:A:G0.6316Enhancer144EliteDistancechr15:101348448-101349807ENSR15_BQ53R
POLR2AZNF687STAT3TBPMYCGATA3FOSTCF7L2MYC
PCSK6GH15J101358-15:101359514:G:T0.8021Enhancer56-Distancechr15:101358512-101360426ENSR15_CD3K5
PKNOX1STAT3FOSMYCFOSMYC
PCSK6GH15J101373-None0.0000Enhancer130-Distancechr15:101373200-101373400ENSR15_84ZGR6
TRIM28ZBTB33ZNF263
PCSK6GH15J101392-15:101392237:G:A0.5889Enhancer1-eQTLs,Distancechr15:101392200-101392600-
SPI1
PCSK6GH15J101397-15:101397557:T:C0.0936Enhancer14-eRNA_co-expression,Distancechr15:101397485-101397595--
PCSK6GH15J101405-15:101405684:TA:T0.0101Enhancer11-eRNA_co-expression,Distancechr15:101405681-101405713--
PCSK6GH15J101425-None0.0000Enhancer36-Distancechr15:101425855-101426005-
ZNF263CHD7KDM1ATCF12SP1EP300NANOG
PCSK6GH15J101426-15:101427596:A:C0.9636Enhancer36-Distancechr15:101426885-101429070-
CTCFSMARCA4MYCCTCF
PCSK6GH15J101434-15:101434515:C:G0.4398Enhancer36-C-HiC,Distancechr15:101434226-101435057-
CEBPBSTAT3STAT3
PCSK6GH15J101436-15:101437253:T:C0.2961Enhancer1-C-HiC,Distancechr15:101436763-101437522-
RBM39FOSRBM22
PCSK6GH15J101438-15:101439293:A:G0.4918Enhancer446EliteeQTLs,C-HiC,eRNA_co-expression,Distancechr15:101438475-101440895ENSR15_5TT7JR, ENSR15_CD3QX
ASH2LFOXA2RESTCREMKDM1AYY1MAXNR2F2HNF4AETV4NR2F6RXRAJUNDSOX13FOXA1GATA4SP1POLR2GHNRNPLLEP300RAD21TAF1TFAP4HNF4GPOLR2AHDAC2SKICEBPBNCOR1FOSL2TCF7CCAR2TBPRBFOX2SMC3RBM22HNRNPLBRD4RBM39AGO2ZBTB33RESTCTCFYY1XRCC5TAF1SIN3APOLR2AZNF24NRF1SP1MNTPKNOX1RXRACUX1RAD21GABPAMYCNR2F2HNF4AMAXZHX2KDM1ATFAP4CREB1FOXK2ZNF217CTBP1ZBTB7ARBFOX2USF1ZBTB33FOXA2MBD2FOXA1RCOR1BHLHE40JUNDHDAC2NR3C1MAFKMAFFCREMFOSL2GATA3TBX3NR2F6NCOR1EP300ASH2LATF2TBL1XR1SMC3EGR1HNF1ASMARCC2ARID3AHDAC1SKIATF3TBPELF1TCF7ETS1TCF12ATF7RBFOX2GATA4SMARCE1HNF4GCEBPBETV4CHD4RBM22SMC3PRPF4ZBTB40FOSCUX1TCF7L2PKNOX1FOXA1GATA3
PCSK6GH15J101440-15:101441024:C:A0.0489Enhancer144EliteDistancechr15:101440955-101441105-
FOSCUX1TCF7L2PKNOX1FOXA1GATA3FOXA2ESR1
PCSK6GH15J101441-15:101442226:G:C0.3136Enhancer98EliteeQTLs,Distancechr15:101441638-101442324ENSR15_93H95D
CTCFSUZ12SPI1
PCSK6GH15J101445-15:101446770:G:A0.6988Enhancer475EliteeQTLs,Distancechr15:101445241-101447504ENSR15_CD3RF
HDAC1KDM1APOLR2AFOSMAXTBX3YY1FOXA1SP1ZBTB33MYCRESTGATA4NR2F6ARID3AATF7FOXK2HNF1AJUNDCREB1USF1FOXA2NCOR1HDAC2RXRAEGR1RAD21HNF4ASTAT3FOSL2BHLHE40TCF7CEBPBNR2F2TBPRBM39EP300CREMAGO2HNRNPLLATF3RBFOX2RBM22POLR2GCTCFATF3GMEB1ATF4EP400ZNF592ZNF24ESRRAE4F1TAF9BE2F1GATA1SKILPKNOX1SMARCC2NCOA1FOXK2JUNDPRDM10HDAC3MYCATF7MEIS2HDAC2KDM1ANEUROD1ARID1BMNTARNTTCF12NRF1EP300TEAD4SMARCA4NFICNBNZEB2GATA2IKZF1CREMJUNCEBPBMTA2FOXA2EGR1MAFKTBPRNF2ZMYM3SMARCE1MLLT1ARID3ATAL1C11orf30CUX1CBFA2T3HES1L3MBTL2DPF2NFRKBKLF16CREB3L1FOSATF2BRD9ZNF318BCORTRIM24MTA1TBL1XR1CBFA2T2BHLHE40NFE2NFATC3ELF1NCOR1GATA3CTBP1MITFMEF2AZNF316MGASTAT3AFF1SOX6LEF1SMARCA5RBM22ASH2LSOX13HNF4ACEBPBTCF7SKIXRCC5ZBTB7AJUNDRXRASP1FOXA1FOSEGR1HNF4GCBFA2T2RBM39JUNATF3FOSL1HNF4AHDAC2BHLHE40ETS1RESTCBFA2T3NR2F1TCF12FOSL2PRDM10CEBPBNR2F6MAFKCTCFZNF24U2AF1RAD21CC2D1ACBX1CBX3CHD4BCORPTBP1ZMYM3RCOR1ESRRARBM25ZNF143SMARCA5MAX
PCSK6GH15J101448-None0.0000Enhancer1-C-HiC,Distancechr15:101448370-101449077-
ZNF274
PCSK6GH15J101450-15:101454729:G:A0.6307Enhancer381EliteeQTLs,Distancechr15:101450229-101454729ENSR15_CD3RR, ENSR15_84ZJH3
RBM22ZBTB7APOLR2GATF7SP1POLR2AYY1ARNTRESTRXRAHNF4AMAXFOXA2GMEB1ZHX2RAD21ZNF274EP400CBFA2T3JUNDEGR1ATF3ZNF24MNTSIN3ANRF1CREMCBFA2T2GATA1DPF2MTA3TCF12RB1NR2F1ZBTB33ARID1BPHF20ZBTB2MGACREB3L1HNRNPLLZBTB7ANCOR1IKZF1ZNF639MYCGABPAKDM4BMTA2ESRRAHDAC3MITFFOXK2MEIS2RNF2SMARCA4PRDM10RAD51TRIM24GATAD2AHDAC1TAL1NBNZEB2MBD2NFICCBX3ZNF282ZKSCAN1KDM1ANFATC3AFF1MTA1TEAD4SKIEHMT2RCOR1E2F8MLLT1GATAD2BSMARCE1NEUROD1CUX1BACH1NCOA1RLFHDAC2PHB2CTBP1JUNFOSL1NR2F2HES1TBL1XR1GATA2SKILCBX1PKNOX1ZSCAN29C11orf30XRCC5BCORELF4TAF9BTBPMXI1TCF7DACH1ZNF316PMLE2F7ZNF318MYNNCTCFKLF16PHF21AMAFKMAFFCEBPBLEF1BHLHE40ETS1EP300CC2D1ASTAT5AIRF2STAT2NFE2UBTFSOX6TFAP4ETV4FOXM1ELF1NFRKBL3MBTL2ZNF384RBFOX2TRIM28IRF1SMARCC2ZNF184GABPB1ZNF592E2F6E4F1CEBPBPRDM10IKZF1ZNF592HDAC2NCOR1GATAD2AYY1TAL1GATA2CBFA2T2SKICBFA2T3SP1RCOR1SMARCA4ZBTB7AHNF4AFOXA2FOXA1RXRANR2F6RBM39ASH2LHNRNPLKDM1AMAXZNF184RESTPOLR2AYY1HNF4GRXRACREMRAD21HNF4ASP1NR2F6TBPSKINCOR1FOXA2HDAC2TFAP4RBM22FOXA1BHLHE40EP300JUNDCTCFATF4ZNF24BCORZFP91
PCSK6GH15J101454-15:101456239:GT:G0.6377Enhancer421EliteeQTLs,C-HiC,Distancechr15:101454938-101456973ENSR15_CD3S4
ZNF24BCORZFP91NFRKBPOLR2ANR2F2GABPAEP300RESTSMARCA4SP1FOXA2MAXYY1IKZF1RAD51BHLHE40RXRAZBTB33ZNF592ATF3USF1HNF4ARAD21TCF7MITFRNF2SKILRCOR1HDAC1ATF7C11orf30KDM1AMXI1SMARCE1HDAC2LEF1DPF2ZEB2ZNF639MTA1HDAC3MTA2TAF9BCBFA2T3ZNF318ZNF316ARID3AMAFKJUNTBL1XR1JUNDMAFFBACH1NFE2ARID1BFOSL1PKNOX1CTBP1GATAD2BMEIS2HNRNPLLHDAC1BHLHE40MAXCREMMNTGATA1ATF2FOXK2EGR1JUNCBFA2T2CBFA2T3ZNF316BACH1MAFKZNF592MAFFC11orf30NFE2BCOR
PCSK6GH15J101458-15:101459164:G:A0.9893Enhancer249EliteC-HiC,Distancechr15:101458173-101460578ENSR15_BQ5MN
PKNOX1MLLT1MAXTFAP4POLR2ACEBPBEP300CTCFATF4MYC
PCSK6GH15J101462-15:101463237:C:T0.6993Enhancer167EliteC-HiC,Distancechr15:101462864-101463979ENSR15_93H9CM
ZNF687SIN3AZNF444ZNF217ELF1CTBP1DPF2GATAD2B
PCSK6GH15J101467-15:101467251:T:C0.7559Enhancer154-C-HiC,Distancechr15:101467129-101473560ENSR15_77Z4NR
CREB1MNTMAXL3MBTL2UBTFE2F6DPF2SMARCA4C11orf30MAFFMAFKZNF592ZNF316NFE2GMEB1RNF2POLR2ACREMRXRAZBTB33YY1FOXA2HNF4AFOXA1SP1IKZF1RBM22UBTFATF2ATF3ATF7JUND
PCSK6GH15J101474-15:101474690:T:C1.4402Enhancer56-Distancechr15:101474038-101475687-
ZNF24FOXA2RBM22
PCSK6GH15J101477-15:101477697:T:C0.4365Enhancer230EliteDistancechr15:101477571-101478624ENSR15_93H9HT
GATA1ARID1BSMARCE1HNF4AIKZF1CTBP1DPF2EHMT2ESRRATEAD4NR2F2ATF7TAL1EP300FOXK2CHD4CBFA2T2GATA2SOX6PRDM10CBFA2T3HDAC2MTA3MAXHDAC1KDM1APHF20SMARCA5BCORZMYM3NFICRBM25NFIBCTCF
PCSK6GH15J101480-15:101480488:C:T0.1181Enhancer133EliteDistancechr15:101480375-101480525-
EP300RFX1BMI1SMARCA4
PCSK6GH15J101481-15:101481652:G:A0.5670Enhancer56-Distancechr15:101481450-101481869-
RBFOX2CREB1POLR2GZNF444CTCFMAXPOLR2A
PCSK6GH15J101484-15:101482129:T:C0.4035Enhancer133EliteDistancechr15:101482015-101482165-
CTCFMAXPOLR2AFOSZBTB33CREB1AGO2PKNOX1
PCSK6GH15J101482-15:101482551:A:G0.2939Enhancer118EliteDistancechr15:101482201-101482576-
CTCFPOLR2AFOSCREB1AGO2PKNOX1RBFOX2
PCSK6GH15J101483-15:101483121:C:G0.3309Enhancer183EliteDistancechr15:101483095-101483368ENSR15_BQ5R6
POLR2ARBFOX2RXRANFIBMNTDPF2ZNF687ZNF217CTBP1
PCSK6GH15J101486-15:101487590:T:C0.6031Enhancer36-Distancechr15:101486455-101487936-
FOS
PCSK6GH15J101488-15:101489563:GGCGCCCCCC:G0.5485Promoter/Enhancer556EliteDistancechr15:101488799-101490001ENSR15_BQ5RZ, ENSR15_5TTJ5L, ENSR15_5TTJ6K, ENSR15_BQ5S6, ENSR15_5TTJ8N, PCSK6_1
EZH2YY1U2AF1PHF8POLR2GRBFOX2RBM39PCBP1KDM5BCREMHNRNPLNCOR1HNRNPLLPOLR2ATAF15TAF1FIP1L1SIN3AAGO1AGO2ZFXKDM4ALEF1L3MBTL2RB1FOXM1SMARCE1ARNTE2F6SUZ12ZBTB7ASAFBPOLR2ACTCFL3MBTL2FOXM1MYCSMARCE1UBTFLEF1RB1CTBP1ZBTB7ATBPE2F6YY1ARNTMAXTAF1ZSCAN29RAD21EGR1NR3C1ASH2LRBM39SUZ12ZFXFOXM1E2F6ARNTHNRNPLLSMARCE1RB1SKIEGR1ZBTB7ARAD21AGO2EZH2KDM4ATAF15HNRNPLZBTB33
PCSK6GH15J101490-15:101490723:T:G0.4139Enhancer189-Distancechr15:101490286-101493774ENSR15_BQ5S6, ENSR15_77Z5NK
RBFOX2CTCFASH2LSUZ12ZFXHNRNPLLAGO2EZH2TAF15HNRNPLZBTB33SETDB1MYCATF3ZNF263FOSJUNDAGO2FOSL2RBFOX2CTCFTRIM28POLR2AGABPB1MYCKDM1ACBFA2T2CBFA2T3L3MBTL2CTCFRAD21RBFOX2POLR2GCEBPBPCBP1PCBP2HNRNPKZNF512BKDM1AZNF444
PCSK6GH15J101495-15:101495692:A:G0.7633Enhancer137-Distancechr15:101495080-101496541ENSR15_BQ5T4
KDM1ASPI1HNRNPKPCBP2POLR2GL3MBTL2RNF2EBF1MGARBM39NR2F2NR2F1IKZF1NR2C1SPI1MAXBHLHE40NR2F6MITFRAD21RAD51CTCFUSF1
PCSK6GH15J101497-15:101497780:T:G0.3445Enhancer261EliteDistancechr15:101497383-101498369ENSR15_93H9PK
EGR1POLR2ATAF1EGR1ATF7NR2F6SIN3ACREMKDM1ATCF12HNF4GTBL1XR1SKIMNTHNF4AJUNDTBPHDAC2RESTCTCFSP1RXRAZSCAN29RAD21NCOR1FOXA1TFAP4MEIS2PRDM10SMARCA4IKZF1LEF1ZEB2NCOR1FOXK2EP300CBFA2T3MTA2GATAD2ASMARCA5ZNF282PKNOX1MGAZMYM3BCORE2F6RBM25NFICBHLHE40MAX
PCSK6GH15J101498-15:101499466:G:C0.3326Enhancer105-Distancechr15:101498966-101499716-
ELF1ZNF217RFX5MYCDPF2SMARCE1CTBP1
PCSK6GH15J101499-15:101500198:C:T0.5816Enhancer297EliteDistancechr15:101499736-101500745ENSR15_BQ5TM
POLR2AYY1RAD21SP1GABPAMNTRXRAMXI1MAXL3MBTL2CTCFHNF4AZBTB33ARNTEGR1FOXA2HDAC1PAX5FOXA1JUNDSMARCA4BHLHE40NR2F2ATF3RESTEP300FOSMAFKNFE2ZSCAN29MYCBATFTCF12MEF2ARUNX3C11orf30FOXA2CTCFNFICYY1PKNOX1
PCSK6GH15J101501-15:101502214:T:TC0.5470Enhancer320EliteDistancechr15:101501600-101502432ENSR15_BQ5TS, ENSR15_93H9QR, ENSR15_5TTLBZ
YY1SP1GATA1CTCFZNF263ASH2LRBM39SIN3ABCL3MTA3ZNF579ZNF217HNRNPLLCTBP1HNRNPLELF1ZNF444TRIM22MAXPKNOX1MYCE2F6ZNF143RAD21SMC3RESTHDAC2XRCC5
PCSK6GH15J101510-15:101510770:G:T0.3119Enhancer133-Distancechr15:101510346-101511114-
SP1HNF4AFOXA1FOXA2NR2F1RXRASP1TRIM24JUNDATF3RAD21HNF4ASPI1ATF4CEBPB
PCSK6GH15J101520-None0.0000Enhancer9-eRNA_co-expression,Distancechr15:101520459-101520582--
PCSK6GH15J101521-15:101521371:T:C0.8099Enhancer126-Distancechr15:101521200-101521800-
RNF2GABPACEBPBFOXA1