GWAS Annotated Elements: PCSK6

Gene: proprotein convertase subtilisin/kexin type 6

Significance Threshold: -log10(P) ≥ 6.0

GHID GWAS Hit Lead SNP -log10P Type Elite Association Location TFBSs
GH15J101022 - None 0.0000 Enhancer Elite eRNA_co-expression chr15:101022978-101025286
NR2F2CEBPBEP300NFE2L2FOSCEBPBMAFKPOLR2A
GH15J101293 - 15:101297404:G:A 0.4659 Promoter/Enhancer Elite Distance chr15:101293014-101297693
TBX21ELF1PAX8BHLHE40ZBED1PAX5BACH1RBFOX2MTA2RAD51NRF1CBFBZEB2ZNF24POLR2AL3MBTL2BCORCTCFSREBF1IKZF1HDAC1RBFOX2BHLHE40SP1CHD1WRNIP1RFX1EBF1CTCFSMARCE1IKZF2ZFXSIN3AELF1TBPSAP30TAF1YY1ELF4MAXATF7ETV4RBFOX2MYCPHF8POLR2AMNTMXI1ZNF687EP400HDAC1ZZZ3EP300SRFPKNOX1BHLHE40UBTFPOLR2GASH2LMEF2BZNF24HNRNPLLNFYBRNF2MGAZNF592L3MBTL2KDM5AHDAC2NRF1RBBP5ZNF639MLLT1RBM22PCBP1ZNF316SREBF2POU2F2IKZF1CLOCKGATAD2BSAFBE2F4STAT1RBM39RCOR1PRPF4RESTNFIBNFICGATA1DPF2ZNF143SP1RELBHNRNPUL1NR2F2ARID3ATAF15BACH1SMAD5TCF7L2CREB3L1SKILFUSZNF263TBL1XR1ZNF217CTBP1EGR1SMAD1FOSL2HNRNPKGABPB1ATF3ZBTB33XRCC5NCOR1ZBED1ELF4GMEB1U2AF1CBX3FIP1L1C11orf30ZNF444SUZ12AGO2ZNF207MEIS2JUNTAF7SMARCA5CUX1TBPE2F7RBM25ARNTE2F8TFAP4GATA2HCFC1CREB1ESRRASTAT5AMTA3SOX6NEUROD1E2F1ELF1FOXM1ZHX2ZBTB7BCREMGATAD2AE2F6MBD2ETS1HNF4ANCOA4KDM4BAGO1TRIM22NR2C2RB1JUNDELK1TCF12RAD51TAF9BSKINR3C1ZBTB40ZNF639KLF5MAFKZBTB7AGABPAFOXK2SMARCA4USF1IRF1SIX5CBFBNBNFOSL1ZMIZ1KDM5ANFE2L2KDM4AGATA3MEF2CTHAP1RUNX3SIN3BSRFE4F1GATA4TRIM24STAT3FOXA1PAX5BCL3ZBTB11ATF7SAP30NCOA1NCOA6HES1PHF20RFX5AFF1ETV4NR2C1ZSCAN29ARID1BPMLZNF830KDM5BRFX1MTA2PTBP1RBM22UBTFMITFNR2F6NR2F1HNF4AHNF4GCBFA2T3PKNOX1MEIS2JUNDGATA3GATAD2BZFXTBPMYCFOSNR3C1CEBPB
GH15J101300 - 15:101300449:C:T 1.1472 Enhancer - Distance chr15:101300415-101300565
CTCFZNF444TRIM22SMC3RAD21ZNF143ZNF384SIN3AREST
GH15J101320 - 15:101321178:G:A 1.0257 Enhancer Elite Distance chr15:101320221-101321444
POLR2AGABPACTCFMAXCEBPBZNF143RAD21
GH15J101324 - 15:101324170:C:T 0.7812 Enhancer - Distance chr15:101324103-101325476
KDM1ASP1MAXATF7RXRAATF3EP300EGR1SPI1HNF4GFOXA1HNF4ACEBPBSMC3FOSL2ELF1MAFFYY1HNF4AHNRNPLJUNDNR2F2HNF4GSP1MAXRXRAATF3AGO2POLR2G
GH15J101325 - 15:101325839:G:A 0.8033 Enhancer - Distance chr15:101325753-101326109
HNRNPLAGO2
GH15J101333 - 15:101333787:T:C 1.1634 Enhancer - Distance chr15:101333206-101335123
CTCFGABPB1NCOA1EP400BRD4NR2C1PHF20IKZF2POLR2AGABPAPHF8ZBTB40KDM5BMTA3TRIM28TRIP13MTA2CREB3L1PKNOX1SMAD5ZNF263EHMT2ATF7SP1E2F1CBX1E2F8RBFOX2ZNF184CREMCBX3BCL3MAXSETDB1ZBTB11TCF12FOXK2JUNPMLELF1SIX5ETS1HCFC1TBL1XR1NR2C2EGR1MYCJUNDATF2TAF1NFE2E4F1CTBP1C11orf30CBX5KDM4BZNF830HDAC1NFRKBATF7ZNF184ZNF316L3MBTL2PKNOX1KLF5RESTPHF20DNMT1MTA2RB1TRIP13PHF8CBX1SIN3BNFATC3
GH15J101348 - 15:101348870:A:G 0.6316 Enhancer Elite Distance chr15:101348448-101349807
POLR2AZNF687STAT3TBPMYCGATA3FOSTCF7L2MYC
GH15J101358 - 15:101359514:G:T 0.8021 Enhancer - Distance chr15:101358512-101360426
PKNOX1STAT3FOSMYCFOSMYC
GH15J101373 - None 0.0000 Enhancer - Distance chr15:101373200-101373400
TRIM28ZBTB33ZNF263
GH15J101392 - 15:101392237:G:A 0.5889 Enhancer - eQTLs,Distance chr15:101392200-101392600
SPI1
GH15J101397 - 15:101397557:T:C 0.0936 Enhancer - eRNA_co-expression,Distance chr15:101397485-101397595 -
GH15J101405 - 15:101405684:TA:T 0.0101 Enhancer - eRNA_co-expression,Distance chr15:101405681-101405713 -
GH15J101425 - None 0.0000 Enhancer - Distance chr15:101425855-101426005
ZNF263CHD7KDM1ATCF12SP1EP300NANOG
GH15J101426 - 15:101427596:A:C 0.9636 Enhancer - Distance chr15:101426885-101429070
CTCFSMARCA4MYCCTCF
GH15J101434 - 15:101434515:C:G 0.4398 Enhancer - C-HiC,Distance chr15:101434226-101435057
CEBPBSTAT3STAT3
GH15J101436 - 15:101437253:T:C 0.2961 Enhancer - C-HiC,Distance chr15:101436763-101437522
RBM39FOSRBM22
GH15J101438 - 15:101439293:A:G 0.4918 Enhancer Elite eQTLs,C-HiC,eRNA_co-expression,Distance chr15:101438475-101440895
ASH2LFOXA2RESTCREMKDM1AYY1MAXNR2F2HNF4AETV4NR2F6RXRAJUNDSOX13FOXA1GATA4SP1POLR2GHNRNPLLEP300RAD21TAF1TFAP4HNF4GPOLR2AHDAC2SKICEBPBNCOR1FOSL2TCF7CCAR2TBPRBFOX2SMC3RBM22HNRNPLBRD4RBM39AGO2ZBTB33RESTCTCFYY1XRCC5TAF1SIN3APOLR2AZNF24NRF1SP1MNTPKNOX1RXRACUX1RAD21GABPAMYCNR2F2HNF4AMAXZHX2KDM1ATFAP4CREB1FOXK2ZNF217CTBP1ZBTB7ARBFOX2USF1ZBTB33FOXA2MBD2FOXA1RCOR1BHLHE40JUNDHDAC2NR3C1MAFKMAFFCREMFOSL2GATA3TBX3NR2F6NCOR1EP300ASH2LATF2TBL1XR1SMC3EGR1HNF1ASMARCC2ARID3AHDAC1SKIATF3TBPELF1TCF7ETS1TCF12ATF7RBFOX2GATA4SMARCE1HNF4GCEBPBETV4CHD4RBM22SMC3PRPF4ZBTB40FOSCUX1TCF7L2PKNOX1FOXA1GATA3
GH15J101440 - 15:101441024:C:A 0.0489 Enhancer Elite Distance chr15:101440955-101441105
FOSCUX1TCF7L2PKNOX1FOXA1GATA3FOXA2ESR1
GH15J101441 - 15:101442226:G:C 0.3136 Enhancer Elite eQTLs,Distance chr15:101441638-101442324
CTCFSUZ12SPI1
GH15J101445 - 15:101446770:G:A 0.6988 Enhancer Elite eQTLs,Distance chr15:101445241-101447504
HDAC1KDM1APOLR2AFOSMAXTBX3YY1FOXA1SP1ZBTB33MYCRESTGATA4NR2F6ARID3AATF7FOXK2HNF1AJUNDCREB1USF1FOXA2NCOR1HDAC2RXRAEGR1RAD21HNF4ASTAT3FOSL2BHLHE40TCF7CEBPBNR2F2TBPRBM39EP300CREMAGO2HNRNPLLATF3RBFOX2RBM22POLR2GCTCFATF3GMEB1ATF4EP400ZNF592ZNF24ESRRAE4F1TAF9BE2F1GATA1SKILPKNOX1SMARCC2NCOA1FOXK2JUNDPRDM10HDAC3MYCATF7MEIS2HDAC2KDM1ANEUROD1ARID1BMNTARNTTCF12NRF1EP300TEAD4SMARCA4NFICNBNZEB2GATA2IKZF1CREMJUNCEBPBMTA2FOXA2EGR1MAFKTBPRNF2ZMYM3SMARCE1MLLT1ARID3ATAL1C11orf30CUX1CBFA2T3HES1L3MBTL2DPF2NFRKBKLF16CREB3L1FOSATF2BRD9ZNF318BCORTRIM24MTA1TBL1XR1CBFA2T2BHLHE40NFE2NFATC3ELF1NCOR1GATA3CTBP1MITFMEF2AZNF316MGASTAT3AFF1SOX6LEF1SMARCA5RBM22ASH2LSOX13HNF4ACEBPBTCF7SKIXRCC5ZBTB7AJUNDRXRASP1FOXA1FOSEGR1HNF4GCBFA2T2RBM39JUNATF3FOSL1HNF4AHDAC2BHLHE40ETS1RESTCBFA2T3NR2F1TCF12FOSL2PRDM10CEBPBNR2F6MAFKCTCFZNF24U2AF1RAD21CC2D1ACBX1CBX3CHD4BCORPTBP1ZMYM3RCOR1ESRRARBM25ZNF143SMARCA5MAX
GH15J101448 - None 0.0000 Enhancer - C-HiC,Distance chr15:101448370-101449077
ZNF274
GH15J101450 - 15:101454729:G:A 0.6307 Enhancer Elite eQTLs,Distance chr15:101450229-101454729
RBM22ZBTB7APOLR2GATF7SP1POLR2AYY1ARNTRESTRXRAHNF4AMAXFOXA2GMEB1ZHX2RAD21ZNF274EP400CBFA2T3JUNDEGR1ATF3ZNF24MNTSIN3ANRF1CREMCBFA2T2GATA1DPF2MTA3TCF12RB1NR2F1ZBTB33ARID1BPHF20ZBTB2MGACREB3L1HNRNPLLZBTB7ANCOR1IKZF1ZNF639MYCGABPAKDM4BMTA2ESRRAHDAC3MITFFOXK2MEIS2RNF2SMARCA4PRDM10RAD51TRIM24GATAD2AHDAC1TAL1NBNZEB2MBD2NFICCBX3ZNF282ZKSCAN1KDM1ANFATC3AFF1MTA1TEAD4SKIEHMT2RCOR1E2F8MLLT1GATAD2BSMARCE1NEUROD1CUX1BACH1NCOA1RLFHDAC2PHB2CTBP1JUNFOSL1NR2F2HES1TBL1XR1GATA2SKILCBX1PKNOX1ZSCAN29C11orf30XRCC5BCORELF4TAF9BTBPMXI1TCF7DACH1ZNF316PMLE2F7ZNF318MYNNCTCFKLF16PHF21AMAFKMAFFCEBPBLEF1BHLHE40ETS1EP300CC2D1ASTAT5AIRF2STAT2NFE2UBTFSOX6TFAP4ETV4FOXM1ELF1NFRKBL3MBTL2ZNF384RBFOX2TRIM28IRF1SMARCC2ZNF184GABPB1ZNF592E2F6E4F1CEBPBPRDM10IKZF1ZNF592HDAC2NCOR1GATAD2AYY1TAL1GATA2CBFA2T2SKICBFA2T3SP1RCOR1SMARCA4ZBTB7AHNF4AFOXA2FOXA1RXRANR2F6RBM39ASH2LHNRNPLKDM1AMAXZNF184RESTPOLR2AYY1HNF4GRXRACREMRAD21HNF4ASP1NR2F6TBPSKINCOR1FOXA2HDAC2TFAP4RBM22FOXA1BHLHE40EP300JUNDCTCFATF4ZNF24BCORZFP91
GH15J101454 - 15:101456239:GT:G 0.6377 Enhancer Elite eQTLs,C-HiC,Distance chr15:101454938-101456973
ZNF24BCORZFP91NFRKBPOLR2ANR2F2GABPAEP300RESTSMARCA4SP1FOXA2MAXYY1IKZF1RAD51BHLHE40RXRAZBTB33ZNF592ATF3USF1HNF4ARAD21TCF7MITFRNF2SKILRCOR1HDAC1ATF7C11orf30KDM1AMXI1SMARCE1HDAC2LEF1DPF2ZEB2ZNF639MTA1HDAC3MTA2TAF9BCBFA2T3ZNF318ZNF316ARID3AMAFKJUNTBL1XR1JUNDMAFFBACH1NFE2ARID1BFOSL1PKNOX1CTBP1GATAD2BMEIS2HNRNPLLHDAC1BHLHE40MAXCREMMNTGATA1ATF2FOXK2EGR1JUNCBFA2T2CBFA2T3ZNF316BACH1MAFKZNF592MAFFC11orf30NFE2BCOR
GH15J101458 - 15:101459164:G:A 0.9893 Enhancer Elite C-HiC,Distance chr15:101458173-101460578
PKNOX1MLLT1MAXTFAP4POLR2ACEBPBEP300CTCFATF4MYC
GH15J101462 - 15:101463237:C:T 0.6993 Enhancer Elite C-HiC,Distance chr15:101462864-101463979
ZNF687SIN3AZNF444ZNF217ELF1CTBP1DPF2GATAD2B
GH15J101467 - 15:101467251:T:C 0.7559 Enhancer - C-HiC,Distance chr15:101467129-101473560
CREB1MNTMAXL3MBTL2UBTFE2F6DPF2SMARCA4C11orf30MAFFMAFKZNF592ZNF316NFE2GMEB1RNF2POLR2ACREMRXRAZBTB33YY1FOXA2HNF4AFOXA1SP1IKZF1RBM22UBTFATF2ATF3ATF7JUND
GH15J101474 - 15:101474690:T:C 1.4402 Enhancer - Distance chr15:101474038-101475687
ZNF24FOXA2RBM22
GH15J101477 - 15:101477697:T:C 0.4365 Enhancer Elite Distance chr15:101477571-101478624
GATA1ARID1BSMARCE1HNF4AIKZF1CTBP1DPF2EHMT2ESRRATEAD4NR2F2ATF7TAL1EP300FOXK2CHD4CBFA2T2GATA2SOX6PRDM10CBFA2T3HDAC2MTA3MAXHDAC1KDM1APHF20SMARCA5BCORZMYM3NFICRBM25NFIBCTCF
GH15J101480 - 15:101480488:C:T 0.1181 Enhancer Elite Distance chr15:101480375-101480525
EP300RFX1BMI1SMARCA4
GH15J101481 - 15:101481652:G:A 0.5670 Enhancer - Distance chr15:101481450-101481869
RBFOX2CREB1POLR2GZNF444CTCFMAXPOLR2A
GH15J101484 - 15:101482129:T:C 0.4035 Enhancer Elite Distance chr15:101482015-101482165
CTCFMAXPOLR2AFOSZBTB33CREB1AGO2PKNOX1
GH15J101482 - 15:101482551:A:G 0.2939 Enhancer Elite Distance chr15:101482201-101482576
CTCFPOLR2AFOSCREB1AGO2PKNOX1RBFOX2
GH15J101483 - 15:101483121:C:G 0.3309 Enhancer Elite Distance chr15:101483095-101483368
POLR2ARBFOX2RXRANFIBMNTDPF2ZNF687ZNF217CTBP1
GH15J101486 - 15:101487590:T:C 0.6031 Enhancer - Distance chr15:101486455-101487936
FOS
GH15J101488 - 15:101489563:GGCGCCCCCC:G 0.5485 Promoter/Enhancer Elite Distance chr15:101488799-101490001
EZH2YY1U2AF1PHF8POLR2GRBFOX2RBM39PCBP1KDM5BCREMHNRNPLNCOR1HNRNPLLPOLR2ATAF15TAF1FIP1L1SIN3AAGO1AGO2ZFXKDM4ALEF1L3MBTL2RB1FOXM1SMARCE1ARNTE2F6SUZ12ZBTB7ASAFBPOLR2ACTCFL3MBTL2FOXM1MYCSMARCE1UBTFLEF1RB1CTBP1ZBTB7ATBPE2F6YY1ARNTMAXTAF1ZSCAN29RAD21EGR1NR3C1ASH2LRBM39SUZ12ZFXFOXM1E2F6ARNTHNRNPLLSMARCE1RB1SKIEGR1ZBTB7ARAD21AGO2EZH2KDM4ATAF15HNRNPLZBTB33
GH15J101490 - 15:101490320:T:TGCAGGTGAACCCCCAGGCCGC 1.8806 Enhancer - Distance chr15:101490286-101493774
RBFOX2CTCFASH2LSUZ12ZFXHNRNPLLAGO2EZH2TAF15HNRNPLZBTB33SETDB1MYCATF3ZNF263FOSJUNDAGO2FOSL2RBFOX2CTCFTRIM28POLR2AGABPB1MYCKDM1ACBFA2T2CBFA2T3L3MBTL2CTCFRAD21RBFOX2POLR2GCEBPBPCBP1PCBP2HNRNPKZNF512BKDM1AZNF444
GH15J101495 - 15:101495692:A:G 0.7633 Enhancer - Distance chr15:101495080-101496541
KDM1ASPI1HNRNPKPCBP2POLR2GL3MBTL2RNF2EBF1MGARBM39NR2F2NR2F1IKZF1NR2C1SPI1MAXBHLHE40NR2F6MITFRAD21RAD51CTCFUSF1
GH15J101497 - 15:101497780:T:G 0.3445 Enhancer Elite Distance chr15:101497383-101498369
EGR1POLR2ATAF1EGR1ATF7NR2F6SIN3ACREMKDM1ATCF12HNF4GTBL1XR1SKIMNTHNF4AJUNDTBPHDAC2RESTCTCFSP1RXRAZSCAN29RAD21NCOR1FOXA1TFAP4MEIS2PRDM10SMARCA4IKZF1LEF1ZEB2NCOR1FOXK2EP300CBFA2T3MTA2GATAD2ASMARCA5ZNF282PKNOX1MGAZMYM3BCORE2F6RBM25NFICBHLHE40MAX
GH15J101498 - 15:101499466:G:C 0.3326 Enhancer - Distance chr15:101498966-101499716
ELF1ZNF217RFX5MYCDPF2SMARCE1CTBP1
GH15J101499 - 15:101500198:C:T 0.5816 Enhancer Elite Distance chr15:101499736-101500745
POLR2AYY1RAD21SP1GABPAMNTRXRAMXI1MAXL3MBTL2CTCFHNF4AZBTB33ARNTEGR1FOXA2HDAC1PAX5FOXA1JUNDSMARCA4BHLHE40NR2F2ATF3RESTEP300FOSMAFKNFE2ZSCAN29MYCBATFTCF12MEF2ARUNX3C11orf30FOXA2CTCFNFICYY1PKNOX1
GH15J101501 - 15:101502214:T:TC 0.5470 Enhancer Elite Distance chr15:101501600-101502432
YY1SP1GATA1CTCFZNF263ASH2LRBM39SIN3ABCL3MTA3ZNF579ZNF217HNRNPLLCTBP1HNRNPLELF1ZNF444TRIM22MAXPKNOX1MYCE2F6ZNF143RAD21SMC3RESTHDAC2XRCC5
GH15J101510 - 15:101510770:G:T 0.3119 Enhancer - Distance chr15:101510346-101511114
SP1HNF4AFOXA1FOXA2NR2F1RXRASP1TRIM24JUNDATF3RAD21HNF4ASPI1ATF4CEBPB
GH15J101520 - None 0.0000 Enhancer - eRNA_co-expression,Distance chr15:101520459-101520582 -
GH15J101521 - 15:101521371:T:C 0.8099 Enhancer - Distance chr15:101521200-101521800
RNF2GABPACEBPBFOXA1