GWAS Annotated: PKM

Gene: pyruvate kinase M1/2

GeneGHIDGWAS HitLead SNP-log10PTypeScoreEliteAssociation EvidenceLocationExternal LinksTFBSs
PKMGH15J072167-15:72169914:C:T0.4120Enhancer222EliteC-HiCchr15:72167321-72171273ENSR15_C96CJ, ENSR15_933MFM
CTCFZNF687ZNF217DPF2ZBTB40ZNF592GATA3HMBOX1POLR2ANR3C1SMARCE1SMARCA4ZEB2SPI1FOXA1CBFA2T2TAL1TCF12TEAD4CTBP1ZBTB7AARID1BCBFA2T3NR3C1NFIBMYCNR3C1ESR1CTCFPOLR2AMYCCREB1SIN3ACTBP1ELF1PKNOX1GATA3ZNF217BHLHE40ZMYM3RBM25
PKMGH15J072175-15:72176736:G:A0.9042Enhancer237EliteC-HiCchr15:72175913-72176785-
TAL1CBFA2T3ZNF24NFIBESR1
PKMGH15J072177-15:72177605:G:C0.2814Enhancer151-C-HiCchr15:72177069-72178688-
ZNF384EP300FOXA1DPF2SMARCE1MAFKNFIC
PKMGH15J072179-15:72179934:C:T0.4090Enhancer192EliteC-HiCchr15:72179176-72181193ENSR15_933MJG, ENSR15_5LZDL2
NR3C1NCOR1SKICTCFRFX1HNF4GNR2F6RAD21HNRNPLEP300STAT3POLR2AKDM1ANR2F6FOXA2RXRASP1FOXA1
PKMGH15J072181-15:72183521:A:AAAC0.5866Enhancer372EliteC-HiCchr15:72181603-72185028ENSR15_845B5G, ENSR15_C96DN
EP300ZNF384ASH2LEHMT2CREMSP1RFX1HNF1ASKIKDM1ARNF2NR2F6TBL1XR1FOXP1FOSRXRAFOXA2EP300FOXA1NCOR1SOX13HDAC2HNF4GCEBPBHNF4ATBX3NR3C1SMC3TFAP4ZNF24RESTHDAC1ZMYM3FOXP1POLR2ARBM39CTCFEZH2NFE2L2ASH2LTAF1ZNF217DPF2TCF12TBPYY1CTBP1HNRNPLLSIN3AELF1PHF8TFAP4NR3C1EP300RXRASUZ12SP1SMARCE1NRF1ZNF444MBD2ZNF579RESTRBBP5MTA1KDM4ACTCFZBTB7BFOSL2DPF2GATA3FOXA1CUX1
PKMGH15J072194-15:72197829:C:G0.5035Promoter/Enhancer667EliteC-HiC,Distancechr15:72194739-72204299ENSR15_BJBSW, ENSR15_C96FK, ENSR15_5LZHHP, ENSR15_933MPM, ENSR15_5LZHM7, ENSR15_5LZHXN, ENSR15_BJBW5, GRAMD2_1
ZNF217ZBTB40CTCFHDAC1IKZF1ELF1POLR2ACTBP1EP300FOXK2SPI1GABPB1POLR2AEZH2SUZ12POLR2GAGO1ASH2LZNF263PHF8CTCFRBBP5ZFXRBFOX2KDM4ASIN3AGABPANFYBTAF15RBM22SP1AGO2STAT5AUBTFMTA3JUNDATF2NFICPBX3RUNX3E2F8NFATC1AGO2BACH1MYNNBCL3PAX5FOXA2RFX1ZNF207TFAP4SIN3AATF3ZNF263CTCFSIN3ARAD21GABPB1XRCC5SMC3ELF1ZNF444CTBP1POLR2AMYNNRBM39RB1KLF5TRIM22ZNF143TCF12RXRACC2D1AYY1ZBTB40NRF1ETV4GATA3CREMNR3C1RESTIRF4ZHX1SPI1HNF4AMYCJUNDMXI1HNF4GRUNX3RFX5PBX3EP300FOSL2E2F8RAD51POLR2ARBM22RAD51USF2BHLHE40EBF1SP1CTCFRBFOX2NFIBAGO2CTCFPOLR2APOLR2ATCF12POLR2GRBM22POLR2GMYCCTCFFOSEP300STAT3MXI1YY1SIN3ARCOR1USF1USF2RFX5BHLHE40TAF1RAD21GATA2DACH1
PKMGH15J072205-15:72206600:T:C0.5217Enhancer117-C-HiC,Distancechr15:72205732-72209108-
RBM22AGO2POLR2APOLR2AATF3SP1ZFXETS1RESTRBM22POLR2GNFIBNFICPOLR2ARBM22
PKMGH15J072209-15:72209800:G:A0.5532Enhancer151-Distancechr15:72209516-72210813-
JUNDPOLR2ASP1POLR2ANCOR1NR2F2CREMTBX3JUNDNR2F6ARID3ACUX1FOXA2TCF7TBL1XR1HNF4AEP300HDAC2
PKMGH15J072210-None0.0000Enhancer242EliteDistancechr15:72210879-72210969-
SP1POLR2ANCOR1NR2F2CREMTBX3JUNDNR2F6ARID3ACUX1FOXA2TCF7TBL1XR1HNF4AEP300HDAC2CEBPBRXRAFOXA1HNF4GSKIESR1KAT2BZNF384
PKMGH15J072212-15:72212484:G:GA0.3617Enhancer63EliteDistancechr15:72212203-72212883-
POLR2ARBFOX2
PKMGH15J072215-15:72216943:G:A0.4499Enhancer133EliteDistancechr15:72215637-72217005-
RBFOX2CEBPB
PKMGH15J072218-15:72219074:G:A0.4711Enhancer56-Distancechr15:72218843-72220226-
POLR2AFOXA1FOXA2RBM22POLR2APOLR2GRBFOX2
PKMGH15J072220-15:72221271:T:A0.5154Enhancer98EliteDistancechr15:72220299-72221428-
POLR2APOLR2GSPI1POLR2A
PKMGH15J072221-15:72224592:T:A0.5671Enhancer222EliteDistancechr15:72221882-72224754ENSR15_BJBZT
RBFOX2POLR2AHCFC1ZNF217MTA1NEUROD1ETS1POLR2GSIN3AHNRNPLNFIBSTAT3SIX5ELF1SP1RFX5MBD2MXI1MNTJUNDUSF2RESTMYCFOSL2CTCFFOSRBM22CEBPBPOLR2ARBFOX2RBM22WRNIP1RBFOX2
PKMGH15J072225-15:72230974:G:C1.1991Promoter/Enhancer755EliteeRNA_co-expression,Distancechr15:72225250-72233252ENSR15_C96HQ, ENSR15_5LZNMN, ENSR15_933N3H, ENSR15_BJC2S, ENSR15_933N3T, ENSR15_BJC36, PKM_1
RBFOX2DPF2WRNIP1SMARCA5CEBPBCTCFPOLR2AZNF687POLR2GRBFOX2MXI1ASH2LTCF12ESRRAAGO2ZNF263SIN3AMNTXRCC5TRIM22ZNF444TBPNFATC1ZBTB7ATRIM28STAT5AMTA3NCOA1RAD21STAT3GATA3FOXA1FOSARNTRESTMAXEGR1KDM5BCBX3ZNF143MEF2BSMARCA5E2F6ZBTB40GATAD2BNR3C1RXRACREMSRFIKZF1ARID3ARB1JUNDSP1RUNX1IKZF2YY1NFATC3MYCZBED1ELF1SKILPRDM10ZNF592TAF1EBF1RUNX3KLF5NFICCHD1BCL3MLLT1EP300ETV6ZNF217JUNRBM22RELBBCL11APAX5BHLHE40MTA2NBNFOSL2ZNF207DPF2POU2F2PKNOX1TBL1XR1JUNBSMAD1MEF2ABATFIRF4CBFBZNF384EEDPBX3ATF7BACH1TBX21PAX8ARID1BKDM1ASMARCE1GATA2STAT3JUNBCREB1JUNDSMARCC2FOSJUNCBFA2T3EHMT2ZEB2MYCATF3TAF1FOSL1FOSL2BATFHCFC1SMARCA5NRF1SMARCA4ZNF592BACH1ESRRATBPPKNOX1POLR2GZNF384RESTGABPASPI1RB1MAFKNFE2L2MAFFZFP91C11orf30ZNF316PKNOX1TAF1NFE2TBPBRD4EBF1RAD51KDM5AYY1MTA2RELBMXI1MYCZNF384EP300PAX5ARNTNFATC3SIN3ADPF2ATF7IKZF1MEF2BSKILPKNOX1SMARCE1SPI1IKZF2CBFBZBED1MLLT1FOSL2ELF1NBNBCL11ARUNX3ZBTB2TBX21MEF2AFOSHDAC3CTCFNFICRESTSMARCA4BHLHE40ETV6GATA1JUNBATF4TCF12ATF3NCOA1ARID1BTAF9BRBFOX2ZSCAN29ZEB2ARID3ABATFCUX1STAT3AFF1GATAD2BRNF2SOX6KDM5BNR2F1CHD1TBL1XR1CEBPBMBD2JUNPRDM10TRIM22MTA3ZNF318NEUROD1EGR1SMAD1RCOR1SP1ZNF282HDAC1DACH1JUNDETS1MAFFZNF143POLR2GE2F8CBFA2T2TRIM24ATF2LEF1POU2F2NCOR1GATAD2AKDM1ANFE2CBFA2T3BACH1HDAC2STAT5ANR2F6KLF16MEIS2MYNNNFATC1GATA2MAFKFOSL1RUNX1SMARCC2CREMEBF1IRF1MTA1HES1NR2F2TAL1RAD21BCORMNTSRFTEAD4ZBTB7AZNF687GATA4CTBP1SMARCA5BACH1ESRRAGMEB1MAXSREBF2TCF7L2STAT1SMAD5RB1NR3C1ZNF217TCF7HMBOX1ZBTB33FOXA1CUX1RAD51TAL1MNTRFX1GATA3SAP30USF1EBF1PKNOX1EEDELF1STAT1MLLT1MAXTAF1RB1L3MBTL2GABPB1GABPABACH1TBPNFICETS1CREB1ZNF687SP1CLOCKRBM39ZFXPTBP1CTCFATF3EZH2U2AF2RBFOX2BHLHE40POLR2GAGO2E2F6HDAC2YY1RAD21SMARCA5FIP1L1GATAD2BHNRNPLLPHF8IKZF1ARNTFUSZNF207TAF15ARID3AHNRNPLPCBP1MTA1EP300LEF1HNRNPKZNF217UBTFRB1SIN3BZNF24TCF12HDAC6SMC3PCBP2ASH2LHDAC1BACH1CCAR2CEBPBELF1ZNF687DPF2CHD1ZNF143ZNF282SP1MYCSMARCE1SOX6HNF4AMEIS2ZNF263MNTTAF7BCL3TBPRNF2GATA4GMEB1RESTZBTB7ACREB1MAXNCOR1BHLHE40KDM1APRDM10EGR1NRF1MEF2AJUNDATF7NR3C1PMLTAF9BMTA2TAL1BCORMLLT1FOXK2ZBTB7BNEUROD1PKNOX1TRIM24ETS1HNRNPH1TBX21GATAD2APAX8IKZF2PRPF4PHF21ARUNX3ZNF24AFF1LCORLE2F8GABPB1NBNSMARCA4DPF2KDM5BBMI1CC2D1ANFRKBZFP91SPI1BATFZBTB40IRF5CREMZEB2ZNF512BCBFA2T3SMAD5NCOA3PAX5E2F6ARID1BTEAD4SMARCA5E2F1SMARCE1SAP30TRIM28CTBP1ELF4NCOA1ASH2LZNF639SMAD1ZBTB2PHF8ZNF444E2F7MIER1ZNF407RELBZNF184RAD51NFXL1TCF12CLOCKZBTB5RFX1ZNF207ARHGAP35SUZ12ZKSCAN1PHB2ZBTB1MITFKDM4AEP400AGO2ZFXAGO1SPI1L3MBTL2C11orf30SMC3PRPF4TAF1UBTFMGACTCFNRF1RCOR1RESTSIN3BZBED1CREB3L1TAF9BATF3MYCBHLHE40FOSL2HCFC1ZSCAN29CBX1FIP1L1ARNTSMAD5TAF7SRFZNF217HNRNPLLSTAT5ATBL1XR1KDM5ASMARCA5TCF7L2MBD2MEF2AZNF384CTBP1MTA3PTBP1IRF1TCF12SOX13POU2F2NFE2L2ESRRAMTA1MAXZBTB11SP1NR3C1HDAC6GABPAYY1KLF5BACH1MITFRBM39RUNX3FOSCBFBRFX1THAP1JUNDPAX5SOX6ZHX1NEUROD1MAFKTBPHNRNPLETV4HDAC2FUSUSF2IKZF2TAF15ZKSCAN1ZNF687ZNF282NCOR1ZNF24SKILRFX5USF1GATA4HNRNPKNFATC3HNRNPUL1RBM34ZBTB7AASH2LCHD7RXRAE4F1GATAD2BELF1ETV6FOXM1ZBTB33ZHX2GMEB1TBX21RBM25KDM1ASTAT1ZNF143TRIM22ZEB1E2F6ATF7ELK1GATA3TBX3XRCC5CBFA2T3ZBTB7BZEB2ARID3ASTAT3ZNF207EGR1BACH1CCAR2E2F4ZBTB2PCBP1GATA2IRF3SMARCE1BCL3ESR1NR2F6SPI1RB1BRCA1JUNSIX5GABPB1TCF7PHF21AGATAD2AHSF1SKIMEF2BFOXA1CREB1LCORLPBX3EEDNCOA1NFIBCREMRAD21NFYBMEF2CNFICCBFA2T2USF1CLOCKTAF7PKNOX1PHF8TFAP4MEIS2SAP30SMAD1KDM4BNFE2L2MYCSREBF2ZBTB40ARID3AFOXA2C11orf30MTA2ZNF316FOXA1MAFFZNF217MAFKAFF1SMARCE1NR2F1E2F1DACH1RFX5EP300MXI1ATF7MNTCTBP1HMBOX1CBFA2T3E4F1ZNF318RNF2ATF3NRF1NR2F6STAT3ELF1ETV4SMARCC2MAXNCOA1HDAC3TRIM28SMARCA4LEF1GATA4KDM1AFOSZNF384MYNNARID1BMYCSTAT5AGATA1TCF7STAT2DPF2IKZF1BHLHE40TAL1JUNHES1JUNDMTA1GABPAHDAC2CREMTBL1XR1NCOR1GATA2TCF12CBFA2T2RAD21NFICPKNOX1TEAD4NFE2NBNRESTNFE2L2ELF4FOSL2TBPMTA2RCOR1MEIS2GATA3SOX6KLF16NR2F2EP300PMLBCORZKSCAN1SREBF2ZBTB33
PKMGH15J072233-15:72235515:G:A0.5429Enhancer130-Distancechr15:72233971-72235824-
SPI1IKZF1HDAC2MTA2KDM1ATEAD4SOX6CBFA2T3CBFA2T2TAL1ARID1BMEIS2NCOR1TCF12ZBTB33PRDM10
PKMGH15J072236-15:72236768:G:A0.5437Enhancer371EliteDistancechr15:72236234-72238893ENSR15_BJC3Z, ENSR15_BJC43
ESRRAJUNDUBTFKDM5BPOLR2GBRD4ZBTB11SREBF1PHF8USF2RFX5TAF1POLR2ASIN3ALEF1TAF9BBCL3YY1EP400MLLT1C11orf30ZBTB33DPF2CBX3IKZF1NFRKBZEB2ZNF318ELF1XRCC5NRF1NCOR1TEAD4NFATC3JUNBZNF316IRF1ATF7HDAC2SMAD5E4F1GABPARESTMNTCBFA2T3HDAC1PKNOX1SOX6PRDM10ARNTMYCZNF263MAFKEP300TBPNBNCREB3L1SMAD1ATF4ESRRARNF2AFF1MBD2ZNF143TRIM24HMBOX1ATF3GABPB1IRF4BACH1IKZF2POU2F2NFE2ZKSCAN1TCF12SP1KDM1ASMARCA4MAXCTBP1FOXA1MAFFHCFC1EEDRCOR1NFE2L2MEIS2RB1FOSL2TAL1NFXL1BATFNEUROD1JUNDJUNMTA1NCOA1MTA3FOSTBL1XR1CREMRELBARID1BBHLHE40SMARCE1ZNF639CEBPBSTAT2ATF2RUNX3MITFSTAT1FOSL1MTA2SPI1RAD51ARID3AUSF1HDAC3HES1GMEB1STAT3ZNF592FOXK2UBTFBCORZBTB33ZMYM3RBM25
PKMGH15J072239-15:72239529:TGA:T0.0200Enhancer56-Distancechr15:72239451-72241317-
ATF2ATF7JUND
PKMGH15J072242-15:72244169:C:T0.5524Enhancer105-Distancechr15:72242527-72244563-
CHD7HDAC2SIN3AKDM1ANANOGRXRAEP300BCL11AUSF1SP1TCF12JUNDEGR1
PKMGH15J072248-15:72249607:C:CA0.7563Enhancer1-Distancechr15:72248501-72250649-
FOSGATA2
PKMGH15J072251-15:72252238:G:A1.1220Enhancer71-Distancechr15:72251194-72252248--
PKMGH15J072265-None0.0000Promoter94-C-HiC,Distancechr15:72265977-72266037PARP6_4-
PKMGH15J072267-None0.0000Promoter94-C-HiC,Distancechr15:72267511-72267571PARP6_2-
PKMGH15J072271-15:72271675:T:G0.7757Promoter/Enhancer572EliteC-HiC,Distancechr15:72271077-72274129ENSR15_BJC92, ENSR15_933NJ9, PARP6_1, PARP6_3
SIN3AZNF263MIER1POLR2AZFXCTCFZNF574GATA3CLOCKZBTB7BRBFOX2RBBP5PHF8UBTFSAP30POLR2GSMARCA4ASH2LDPF2SREBF2SIN3ACHD1SMARCA5MTA1KDM4ASUZ12MXI1JUNDYY1SMARCE1STAT5AKDM5BFOXM1ARNTIKZF1RB1NR3C1ZBTB7ANRF1ARID3AEGR1BHLHE40SKILGATAD2BHDAC2EP300KDM1AL3MBTL2RNF2BACH1ZNF592ZNF282CTBP1EP400CTCFRFX1ZNF687RBM34MAXTHAP1PAX5PKNOX1HNRNPKMNTMYCPMLCREB3L1CBX1STAT2E2F6SMAD5NFYBCREMCBFA2T2MTA3RFX5ATF7RESTMGAMEIS2SP1FOSGMEB1ATF3RBM25ZNF24CREB1TBPCBX3ZNF639IRF3TAF1HDAC1USF2TAF15FOXK2MBD2USF1ESRRAIKZF2MAFKSOX6TEAD4RAD51JUNDTCF12SETDB1SAFBZBTB33HCFC1ETS1GABPB1ZKSCAN1TAF7ZBTB2E4F1XRCC5CBFBMTA1JUNSTAT3E2F8ARNTSMARCA4CHAMP1RXRAZNF574EEDMLLT1TRIM24ELF4HNRNPLLMTA2ATF2BCORPRDM10SIX5ZBTB7BNBNRELBCBFA2T3BCL3ELF1RAD21KLF5NEUROD1TBL1XR1SMARCE1TRIM22ZEB2ZNF263ZNF143PHF20C11orf30IRF2ZNF444ZEB1SMC3ZNF217ZNF207SMARCA5SPI1CC2D1AFOXM1ZBTB40STAT3ZNF316CHD1ELK1MAFKZNF579RUNX3IKZF1MTA2ARID3A
PKMGH15J072287-None0.0000Enhancer105-C-HiCchr15:72286039-72286189ENSR15_933NN5, ENSR15_5M23PX
CTCFHDAC1ZNF444SMC3RAD21ZNF143POLR2AHDAC2RESTTRIM22
PKMGH15J072286-None0.0000Promoter191-C-HiCchr15:72286219-72286279ENSR15_933NN5, CELF6_2
CTCFHDAC1ZNF444SMC3RAD21ZNF143POLR2AHDAC2
PKMGH15J072540-None0.0000Enhancer44-eRNA_co-expressionchr15:72540425-72540628-
TRIM28ZMYM3